In color-multiplexed optical camera communications (OCC) systems, data acquisition is restricted by the image processing algorithm capability for fast source recognition, region-of-interest (ROI) detection and tracking, packet synchronization within ROI, estimation of inter-channel interference and threshold computation. In this work, a novel modulation scheme for a practical RGB-LED-based OCC system is presented. The four above-described tasks are held simultaneously. Using confined spatial correlation of well-defined reference signals within the frame’s color channels is possible to obtain a fully operating link with low computational complexity algorithms. Prior channel adaptation also grants a substantial increase in the attainable data rate, making the system more robust to interferences.